Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic -Cells
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چکیده
The mechanisms by which hypoglycemia stimulates glucagon release are still poorly understood. In particular, the relative importance of direct metabolic coupling versus paracrine regulation by -cell secretory products is unresolved. Here, we compare the responses to glucose of 1) -cells within the intact mouse islet, 2) dissociated -cells, and 3) clonal TC1-9 cells. Free cytosolic concentrations of ATP ([ATP]c) or Ca 2
منابع مشابه
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OBJECTIVE The intraislet insulin hypothesis proposes that glucagon secretion during hypoglycemia is triggered by a decrease in intraislet insulin secretion. A more recent hypothesis based on in vivo data from hypoglycemic rats is that it is the decrease in zinc cosecreted with insulin from beta-cells, rather than the decrease in insulin itself, that signals glucagon secretion from alpha-cells d...
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تاریخ انتشار 2005